serine protease domain meaning in English
丝氨酸蛋白酶功能区
Examples
- The cub domain and serine protease domain 01 clsp closely resembled the corresponding domains of clr ( 48 % and 58 % identity , respectively )
Clsp的cub结构域和丝氨酸蛋白酶结构域与clr相应的结构域之间的相似性( simllarity )分别为为48 %和58 % 。 - Clr is a complement serine protease , composed of two cub ( clr / cls , an embryonic sea urchin protein uegf , and bone morphogenetic protein i ) domains , one egf domain and one serine protease domain
补体组分c1r含有两个cub结构域，一个egf结构域和一个丝氨酸蛋白酶结构域，是一种丝氨酸蛋白酶原。 - For trypsin - like serine protease domain , the presence of his ( h ) - asp ( d ) - ser ( s ) representing a serine protease catalytic triad were at position of 283 , 339 , 436 , respectively
Clsp在正常人外周血单核细胞来源的dc中有较强的表达，在分别经anti一cd40 、 tnf一a 、 lps刺激后的dc中，其表达水平均有所上升。 - The clsp gene is located approximately 3 kb and 90 kb centromeric to the clr and cls gene , respectively , and their genes form a short cluster in a region of about 115kb in 12pl3 . the cluster gene arrangement and the sequence similarities of the cub and trypsin - like serine protease domain of clsp with other complement component 1 subcomponents supported a common evolutionary history by consecutive gene dup
同样利用pcr检测了clspmrna在人正常组织中的分布，结果发现，人clspmrna广泛表达于人正常组织中，如在胎盘、肝脏、肾脏、胰腺中表达量较高，在肺、脾、前列腺、卵巢、结肠、外周血组织有中度表达，而在心脏、骨骼肌、胸腺、翠 - Hydrophobicity analysis predicted a 36 - residue hydrophobic signal peptide for secretion in the n - terminus , and no transmembrane region was present , suggesting it might be a type of secretory protein . some generic and atipical n - glycosylation sites were present in clsp , suggesting that the protein might represent a glycoprotein . the clsp protein contained one cub ( clr / cls , an embryonic sea urchin protein uegf , and bone morphogenetic protein i ) domain from 39th to 164th ammo acids , which is known to be involved in protein - protein or protein - substrate interaction , and a trypsin - like serine protease domain positioned from 244th to 483rd amino acids
Clsp分子具有补体样丝氨酸蛋白酶的多种结构特征，包括36个氨基酸组成的疏水信号肤，一个cub ( clr / cls ， anembryonicseaurehinproteinuegf ， andbonemorphogeneticproteinl )结构域和一个胰酶样丝氨酸蛋白酶结构域( t汀psin一likeserineproteasedomain )和几个保守的糖基化位点等，没有发现有跨膜区的存在。